MALE FERTILITY LIST ;
· PANAX GINSENG GINSENOSIDE RG1
· MACA ROOT MACAENE
· TRIBULUS TERRESTRIS PROTODIOSCIN
· D-ASPARTIC ACID (D-AA)
· TONGKAT ALI EURYCOMANONE
FEMALE FERTILITY LIST ;
FEMALE LIST
Aphrodisiac component of maca identified ; "P-METHOXYBENZYL ISOTHIOCYANATE"
METHYLFOLATE
PABA OR L-ARGININE
MYO-INOSITOL
PYNCNOGENOL
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PABA
p-Aminobenzoic acid, also known as 4-aminobenzoic acid or PABA
PABA Study Shows 75% Success Rate with Getting Pregnant
https://natural-fertility-info.com › paba-study-shows-7...
Jul 24, 2021 — A study reveals that taking PABA regularly can boost fertility and help you get pregnant without invasive infertility treatments.
https://natural-fertility-info.com/paba-study-shows-75-success-rate.html
Is PABA good for fertility?
Some previously infertile women have become pregnant after supplementing with PABA (para-aminobenzoic acid), 100 mg four times per day. PABA is believed to increase the ability of estrogen to facilitate fertility. In one study, infertile couples given vitamin E showed significantly improved fertility.
L-ARGININE
Enhanced Blood Circulation: L-Arginine promotes nitric oxide production, which dilates blood vessels and boosts blood flow. This can potentially improve ovarian blood supply, giving those eggs an extra push!
L-Arginine: The Fertility Dynamo
L-Arginine, a semi-essential amino acid, isn't just another name in the vast world of neutraceuticals. Its power-packed benefits, particularly in the domain of women's fertility, have made it a buzzword in the health and wellness community. But why all the hype? Let’s break it down, point by point.
Enhanced Blood Circulation: L-Arginine promotes nitric oxide production, which dilates blood vessels and boosts blood flow. This can potentially improve ovarian blood supply, giving those eggs an extra push!
Hormonal Balance: It plays a role in regulating hormones linked to ovarian function, aiding in regular menstrual cycles.
Improved Egg Quality: By battling oxidative stress, L-Arginine may contribute to healthier, more viable eggs.
Elevated Sexual Response: For the ladies looking to reignite that spark, L-Arginine can enhance sexual sensitivity and arousal!
Endometrial Receptivity: A healthier endometrium means a higher chance of embryo implantation.
Mitigating PCOS Symptoms: Some studies suggest that L-Arginine can be a beacon of hope for those battling Polycystic Ovary Syndrome.
Combatting Female Sexual Dysfunction: Yup! It's a real thing. And L-Arginine could be a potential remedy.
Ovulatory Function Improvement: For those facing ovulation challenges, guess what? L-Arginine might be your knight in shining armor.
Augmented Cervical Mucus: It's essential for conception. And L-Arginine can boost its quality and quantity.
Strengthened Immune System: A strong immune system means a healthier reproductive system, and L-Arginine has got your back on this!
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Methylfolate- Folic Acid (L-Methylfolate/5-MTHF Methylfolate)
levomefolic acid, also known as l-methylfolate
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Myo-inositol is a key supporter of fertility in a number of ways:
Reduces insulin resistance (helping those with PCOS to conceive)
Controls hormones connected with ovulation
Increases your chances of conception by reducing AMH (anti-Mullerian hormone) levels
Improves egg quality
Prevents problems during pregnancy
Improves fertility in women undergoing assisted reproductive techniques
Myo-inositol is a key supporter of fertility in a number of ways: Reduces insulin resistance (helping those with PCOS to conceive) Controls hormones connected with ovulation. Increases your chances of conception by reducing AMH (anti-Mullerian hormone) levels.
Will myo-inositol help me get pregnant?
Myo-inositol's can be beneficial in improving fertility because of its effectiveness in women with PCOS, in vitro fertilization (IVF) procedures and pregnancy.Aug 14, 2015
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Methylfolate- Folic Acid (L-Methylfolate/5-MTHF Methylfolate)
levomefolic acid, also known as l-methylfolate
https://pubchem.ncbi.nlm.nih.gov/compound/5-Methyltetrahydrofolate
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The Pycnogenol group had the added benefit of maintaining regular menses and normal estrogen levels during treatment, whereas the leuprorelin group had ...
pycnogenol is a potent antioxidant that helps decrease the breakdown of NO* and has been shown to be quite effective for stimulating NO*.
https://goivf.com/fertility-supplements/
Pycnogenol - extract from French maritime pine bark (Pinus pinaster), as an effective antioxidant against superoxide radical
Pycnogenol contains substances which act against cramps and decrease pain. In women with endometriosis, studies showed that 100mg/day for 3 months dramatically decreased pain and other related symptoms and increased pregnancy rates... Women with menstrual cramps and endometriosis have been amazed at the effects of pycnogenol on their pain levels
(http://gilliansanson.wordpress.com/2007/04/29/new-hope-for-endometriosis-and-period-pain-sufferers/
Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8094745/
French maritime pine bark extract has been shown to promote benefits for endometriosis, a leading cause of infertility in women. In addition to relieving endometrial pain and related symptoms, French maritime pine bark extract may also improve pregnancy rates.
https://bloomhealthier.com/pages/pine-bark
.........helps prevent the breakdown of nitrous oxide in the blood stream and at the ovarian level. Nitrous oxide dilates blood vessels, increasing blood flow and oxygen availability to cells. Poor oxygen availability harms cells and leads to cell breakdown whereas relaxed blood vessels, strong blood flow and plenty of oxygen helps prevent oxidative stress, promote cellular repair and prevent egg aging.
https://alexandramackillop.com/2022/05/26/fertility-supplements-for-egg-health-and-egg-freezing/
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MACA
Maca contains biologically active aromatic isothiocyanates, especially p-methoxybenzyl isothiocyanate, which have reputed aphrodisiac properties.
a) The libido boosting compound in Maca was first observed in this study where the researchers identified a compound called “p-methoxybenzyl isothiocyanate” from the root and found out that it had aphrodisiac like activity.
https://anabolicmen.com/maca-testosterone-libido/#google_vignette
https://www.gaiaherbs.com/blogs/seeds-of-knowledge/maca-root-for-libido
https://www.incahealth.com/maca.html
Lepidium Meyeni, Maca is an adaptogen - Inca Health
incahealth.com
http://www.incahealth.com › maca
isothiocyanate aphrodisiac maca from www.incahealth.com
Maca contains biologically active aromatic isothiocyanates, especially p-methoxybenzyl isothiocyanate, wich have reputed aphrodisiac properties. Maca (Andes ...
Benzyl isothiocyanate
Wikipedia
https://en.wikipedia.org › wiki › Benzyl_isothiocyanate
Benzyl isothiocyanate (BITC) is an isothiocyanate found in plants of the mustard family. Benzyl isothiocyanate. Names. Preferred IUPAC name.
https://pubchem.ncbi.nlm.nih.gov/compound/Macaridine
https://www.analytice.com/en/laboratory-determination-of-macaridin-cas-405914-36-5-in-maca-powder/
Maca (L. meyenii) for improving sexual function: a systematic review
The potential bioactive ingredients in maca include macaridine, macamides, macaene, gluosinolates, maca alkaloid, and maca nutrients [14]. However, these data are insufficient for determining whether maca is clinically effective. Currently, no systematic review of this subject is available.
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-10-44
Preserves Cognitive Function
The main alkaloid in maca root extract is macaridine besides is rich in several essential fatty acids. These extracts maca help improve cognitive function and slow down age-related cognitive decline effectively improving memory and concentration.
MACAMIDES - FIVE
https://www.drugs.com/npp/maca.html
alkaloids. The most valuable biologically active substance is macaridin alkaloid, found only at the root of maca.
https://www.scielosp.org/article/rpmesp/2014.v31n1/100-110/en/
https://herbalterra.com/herbal-medicine-news/ultimate-guide-maca-root
https://pubmed.ncbi.nlm.nih.gov/?term=red+maca%20%20%20
Glucosinolates and isothiocyanates
Glucosinolates and isothiocyanates have anticancer activity and may be responsible for some of the activity in the plant species. The aromatic isothiocyanates may be associated with aphrodisiac activity.
https://www.drugs.com/npp/maca.html
Nutritional values of Red Maca
Maca root is a source of various nutrients: carbohydrates, fiber, vitamins, minerals and many amino acids compared to the yellow and black variants. It donates some compounds exclusive to maca such as macamides, macaridin, alkaloids and glucosinolates, to which the effects of the plant have been attributed. The root also provides trace elements, plant sterols and the amino acid L-arginine - useful as a vasodilator agent.
https://www.naturadoriente.com/en/algae-and-berries/898-red-maca-powder-bio.html
"N-benzyl-9Z,12Z-octadecadienamide" +fertility female MACAMIDE
N-benzyl-9Z,12Z-octadecadienamide is the richest compound in the Yunnan maca [
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197015/
https://examine.com/supplements/maca/research/
https://www.scielo.br/j/babt/a/YSZYNdDzf6WdNQLz7vpbwvw/?lang=en#
Macamides are a distinct class of compounds present in Maca roots.4 They are benzylalkylamides, which exhibit many biological functions such as improving sexual potential and neuroprotective, anti-inflammatory, anticancer, and antifatigue effects.
N-(3-Methoxybenzyl)-(9Z,12Z)-octadecadienamide and N-benzyl-(9Z,12Z)-octadecadienamide (compounds 108 and 110) are two representatives of the identified macamides (Table 3 and Figures S13–14).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134390/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134390/#tbl3
Figure 1. Structural formulas of five typical macamides. (a): N-benzyl-hexadecanamide (NBH), (b): N-benzyl-9Z,12Z,15Z-octadecatrienamide, (c): N-(3-methoxybenzyl)-9Z,12Z-octadecadienamide, (d): N-benzyl-9Z,12Z-octadecadienamide, (e): N-(3-methoxybenzyl)-9Z,12Z,15Z-octadecatrienamide.
N-benzyl-hexadecanamide is the active maca ingredient that is responsible for the antifatigue effects
https://www.hindawi.com/journals/jfq/2017/3749627/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426638/
Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468664/
Macamides were reported as one of the important secondary metabo-lites of Maca with neuroprotective, anti-fatigue, improving fertility and sexual functions eects. What’s more, β -carboline alkaloids (A121) and macaridines (A66, A67) were also detected in present analysis, the contents of which were 0~1.6 mg.g−1 and 1.47~72.61 mg.g−1. β -carboline alkaloids displayed neuroprotective eec
Maca presents three major phenotypes, red, yellow and black
differences in the chemical composition of the phenotypes are associated with the reported biological effects or medical target for which these different types can be used. For example, black maca is useful in stimulating sperm count (Gonzales et al., 2006) while red maca is most useful for the treatment of benign prostate hyperplasia (Gonzales et al., 2005). Black maca has been also reported to increase memory and learning in mice (Rubio et al., 2006, Rubio et al., 2007).
https://www.sciencedirect.com/science/article/pii/S0031942215000965
Other reported properties which may not be related to phenotype include increases in female fertility and libido
https://www.sciencedirect.com/science/article/pii/S0031942215000965#b0165
Maca contains sterols, such as campesterols (27.3%), ergosterol (13.6%), brassicasterol (9.1%) Δ7,22-ergostadienol (4.5%) and sitosterol (45.5 %) [23], the latter having phytoestrogen activity. It has been suggested that β-sitosterol could cross the placenta [24]. In humans, it has been demonstrated that sitosterol can be excreted in milk and therefore, enter the neonate [25]. Maca chemical composition includes sitosterol, this compound would exert its effect on pups. Yellow Maca increase the number of pups in normal adult female mice.
Fig. 2. The main maca glucosinolate and metabolites analysed in this study. BGl (1): benzylglucosinolate, BITC (2): benzyl isothiocyanate, BIOC (3): benzyl isocyanate, BCN (4): benzyl nitrile, BOH (5): benzyl alcohol, BCHO (6): benzaldehyde, BNH2 (7): benzylamine, hexanal (8), FFA 18:2 (9): linoleic acid (9), FFA 18:3 (10): linolenic acid, MAC 16 (11): N-benzyl hexadecanamide, MAC 18:2 (12): N-benzyl-(9Z,12Z)-octadecadienamide, MAC 18:3 (13): N-benzyl-(9Z,12Z,15Z) octadecatrienamide.
https://www.sciencedirect.com/science/article/pii/S0031942215000965#b0165
https://onlinelibrary.wiley.com/doi/10.1002/jsfa.9318
6.2. Female Reproduction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184420/
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Uterotonic Plants and their Bioactive Constituents
Examples of isolated and identified uterotonic plant compounds include diterpenes (kaurenoic acid, grandifloric acid and kauradienoic acid; isolated from Montanoa tomentosa and Aspilia mossambicensis) [108–110], phenylpropanoid glucosides (Z-venusol; Gunnera perpensa), [111], heterocyclic aldehydes and fatty acids (5-hydroxymethylfurfural and linoleic acid; Clivia miniata), [75,77], steroidal saponins (pennogenin glycosides; Paris polyphylla) [112], plant sterols (β-sitosterol; Punica granatum) [113] (Fig. 3), and circular polypeptides, so-called cyclotides.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407953/
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GENERAL LIST ;
2. Iron
3. CoQ10
4. Myoinositol
6. Maca root
7. Choline
8. Selenium
9. Iodine
10. Black Cohosh
11. Shatavari root extract
12. Grape seed extract
13. Lycopene
14. L-arginine
16. Pycnogenol
17. Stinging nettle root extract
18. Para-aminobenzoic acid
19. BioPerine
21. D-aspartic acid
22. Longjack root
23. L-Carnitine