WHATS NEW AND EXCITING AT S.O.S
?
INCREASING THE LENGTH OF TELOMERES
ANTI-AGING EXOTIC
CUTTING EDGE TECHNOLOGIES
KEY POINTS ;
The Carl
Baugh Phenomenon
ANTIAGING &
Yamanaka Factors and Making Old Cells Young
Aging is not a
one-way process thanks to partial cellular reprogramming.
Irisin lengthens telomeres. Telomere shortening
is a genetic marker of aging.
Irisin also decreases with age. Increasing irisin
may therefore decrease aging.
Hyperbaric
oxygen therapy increases telomere length and decreases immunosenescence
in isolated
blood cells : a prospective trial Israeli scientists say they have managed to
successfully
reverse the biological aging process – using only oxygen.
The Carl
Baugh Phenomenon
Three scientists
lived on the floor of the ocean for about 1-3 months in a biosphere.
When they left they were all middle aged with
graying hair and low libidos.
When they returned their hair was clear of gray,
their wrinkles had started to disappear, and their sex drive was so increased
that their wives complained to NASA about it.
It turns out that certain glands and organs were
"reactivated." One in particular was the gland that lies over the top
of the heart. Blood tests showed unusual hormones. Hormones that are normally
associated with the growth of young children.
Carl Baugh achieved
phenomenal rejuvenation and other effects with a hyperbaric oxygen Biosphere
plus EMF / frequencies. Dr. Baugh's experiments with his special hyperbaric
biosphere have produced fascinating results that indicate potential methods to
heal and/or rejuvenate people today.. NASA has even requested Dr. Baugh's
research and discoveries to determine their applicability to the space program.
examples include;
extended life span of drosophila fruit flies up to
three generations, molecular change of venom in copperhead snakes to a
non-toxic state, accelerated growth of piranha fish - from 2" to 16"
over a 2.5 years period.
The Hyperbaric Biosphere patent allows for the ability
to vary the mix of gases comprising the atmosphere in the chamber as well as to
vary the electromagnetic field intensity, frequency and duration.
the gnarled 'spaghetti-like' formation of
copperhead snake venom as seen under the scanning electron microscope before
the copperhead snake was 'housed' in a small hyperbaric chamber.
After four weeks in the hyperbaric chamber, venom
from the same copperhead snake shows a much less distorted structure (less
gnarled) indicating a lowering of the toxicity level.
CJT Enterprises wrote:
Hi everyone,
A friend of mine who worked for the NSA related an
experiment that was conducted by NASA. Three scientists lived on the floor of
the ocean for about 1-3 months in a biosphere.
When they left they were all middle aged with
graying hair and low libidos.
When they returned their hair was clear of gray,
their wrinkles had started to disappear, and their sex drive was so increased
that their wives complained to NASA about it.
It turns out that certain glands and organs were
"reactivated." One in particular was the gland that lies over the top
of the heart. Blood tests showed unusual hormones. Hormones that are normally
associated with the growth of young children.
http://rexresearch.com/baugh/baugh.htm
…………………………………………………………………………………………………………………………………………………………….
DNA FREQUENCIES – CRAZY STORIES FROM OUR USERS
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DNA REGENERATION
: INCREASING THE LENGTH OF TELOMERES
A device, method and system
for the microwave resonance therapy of the chromosomes, telomeres and DNA, and
extending the length of telomeres, by generating a wide and uniformly
distributed spectrum of electromagnetic frequencies and ultrasound vibrations
that induce electromagnetic and ultrasonic resonance in chromosomes and
telomeres, and electromagnetic resonance in DNA. A plurality of sharp
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http://rexresearch.com/elstatherapy/elstatherapy.html
WHATS NEW AND EXCITING AT S.O.S
?
In a First, Scientists
Say They've Partially Reversed a Cellular Aging Process in Humans
The
participants sat in a hyperbaric oxygen chamber for five 90 minutes sessions
per week over three months, and as a result, some of their cell's telomeres
were extended by up to 20 percent....the fact that hyperbaric oxygen therapy
appears to affect telomere length is a compelling link worth investigating
further. ... we have realised that changes in the outside environment may
affect the core cellular changes that happens along ageing," said Efrati.
A real achievement would be to flip our chromosomal hourglass completely and
return lost sections of telomere. The fact that high-turnover tissues lining
our gut do this naturally using an enzyme called telomerase has fuelled research
over the years.
There have been plenty of milestones in attempts
to achieve this task. Gene therapy in mice has shown it could one day be
feasible in humans. More recently, stem cells from a supercentenarian woman had
their telomeres completely reset outside of her body.
Some studies have found potential for tiny
increases of maybe a few percent with provision of nutritional supplements such
as vitamin D....this latest study found telomeres in white blood cells taken
from 26 subjects had regained around a fifth of their lost length. The
key, it seems, is hyperbaric oxygen therapy (HBOT) – the absorbing of pure
oxygen while sitting in a pressurised chamber for extensive periods; in this
case, five 90 minute sessions per week over three months.
HBOT has attracted controversy in the past for
claims it could treat a range of conditions. It's usually the kind of therapy
you'd give a diver who came up too fast from the ocean depths, or to kill off
oxygen-sensitive microbes in a wound that just won't heal any other way.
But oxygen-rich environments are also behind a
weird paradox, one where the body desperately stirs up a host of genetic and
molecular changes that typically occur in a low oxygen one.
In this study, the researchers were able to show
that the genetic changes provoked by the HBOT has extended telomeres, and also
had a potentially positive effect on the health of the tissues themselves.
A slightly smaller sample of volunteers also
showed a significant decrease in the number of senescent T cells, tissues that
form a vital part of our immune system's targeted response against invaders.
https://www.sciencealert.com/oxygen-therapy-found-to-turn-back-the-sands-of-time-on-our-body-s-aging-cells?fbclid=IwAR0gOsEA5RLSwK52yGbdkkDdJgQPfwJylXEDZffkVVSpZ7AcJXsF1k2xoD8
ANTI AGING FREQUENCY
TECHNOLOGIES
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Yamanaka Factors and
Making Old Cells Young
https://www.lifespan.io/news/oskm
https://www.youtube.com/watch?v=cMHidJukbgo&feature=emb_logo
In 2006, a study by
Drs. Kazutoshi and Shinya Yamanaka showed that it was
possible to reprogram cells using just four master genes named Oct4, Sox2,
Klf4, and c-Myc, or OSKM for short [1]. These four
reprogramming factors are often called the Yamanaka factors after one of their
discoverers.
Prior to this, it was
assumed that egg cells (oocytes) would contain a complex array of factors
needed to reprogram a somatic cell into becoming an embryonic cell. After all,
the feat of transforming an aged egg cell and reprogramming it to make a new animal
must be controlled by many factors present in the egg cell, or so they thought.
Takahashi and
Yamanaka turned this idea upside down when they showed that just four of the
Yamanaka factors were needed to achieve this transformation. They used the Yamanaka
factors to reprogram adult mouse fibroblasts (connective tissue cells) back to
an embryonic state called pluripotency, a state where the cell behaves like an
embryonic stem cell and can become any other cell type in the body.
This discovery paved
the way for research into how these Yamanaka factors might be used for cellular
rejuvenation and a potential way to combat age-related diseases.
Yamanaka factors for
cellular and animal rejuvenation
In 2011, a team of
French researchers, including Jean-Marc Lemaitre, first reported cellular
rejuvenation using the Yamanaka factors [2]. During their life, cells express
different patterns of genes, and those patterns are unique to each phase in a
cell’s life from young to old; this gene expression profile makes it easy to
identify an old or young cell. At the time, it was also known that aged cells
such as fibroblasts have short telomeres and dysfunctional mitochondria, two of
the nine reasons we age [3].
Jean-Marc Lemaitre
and his colleagues tested the effects of Yamanaka factors on aged fibroblasts
from normal old people and also from healthy people over 100 years old. They
added two additional pluripotency genetic factors to the OSKM mix, namely NANOG
and LIN28, and examined the effect that this had on the gene expression,
telomeres, and mitochondria of these older people.
They discovered that
together, the six factors were able to reset cells from old donors back into a
pluripotent state, meaning that they could become any other cell type in the
body. These became known as induced pluripotent stem cells (iPSCs).
The researchers noted
that the cells had a higher growth rate than the aged cells they had been
reprogrammed from; they also had longer telomeres as well as mitochondria that
behaved in a youthful manner and were no longer dysfunctional. In other words,
reprogramming the cells reversed some of the aspects of aging and rolled the
cells back to a similar state as during development.
Yamanaka factors
appear to reverse epigenetic aging
The final step for the
researchers was to then guide these iPSCs to become fibroblasts again using
other reprogramming factors. The result was that these reprogrammed fibroblasts
no longer expressed the gene patterns associated with aged cells and had a gene
expression profile indistinguishable from those of young fibroblasts.
Essentially, they showed that epigenetic alterations (changes to gene
expression patterns), a reason we age, were reversed.
WHY WE AGE:
EPIGENETIC ALTERATIONS
Epigenetic alterations
are age-related changes in gene expression that harm the fundamental functions
of cells and increase the risk of cancer and other age-related diseases. One of
the proposed reasons we age is the changes to gene expression that our cells
experience as we get older; these are commonly called epigenetic alterations.
These alterations harm the fundamental functions of our cells and can increase
the risk of cancer and other age-related diseases.
Read More
https://www.lifespan.io/topic/epigenetic-alterations/
In addition to this,
they also showed that telomere length, mitochondrial function, and oxidative
stress levels had all reset to those typically observed in young fibroblasts.
Telomere attrition and mitochondrial dysfunction are two more reasons that we
are thought to age.
This was the first
evidence that aged cells, even from very old individuals, could be rejuvenated,
and this was followed by a flood of independent studies confirming these
findings in the same and other types of cells.
Can Yamanaka factors
be used in living animals?
It was easy to
isolate cells in a dish, take them back to a developmental state, then guide
them to become whatever cell type they wanted using Yamanaka factors. But this
was obviously not practical in a living animal as cells could not have their
memory erased so they reverted to a pluripotent state. Imagine if a heart cell
forgot it was a heart cell while it was supposed to be helping pump blood
around the body!
There was also the
concern that the expression of Yamanaka factors was known to induce cancer in
animals [4].
Some researchers
believed that it might be possible to avoid cancer and reverse aging in old
cells without completely reverting them to pluripotency. In other words they
thought there was a way for us to have our cake and eat it. But no one had
successfully managed to achieve this in living animals. This was all about to
change in December 2016.
Professor Juan Carlos
Izpisua Belmonte and his team of researchers at the
Salk Institute reported the conclusion of their study, which showed for the
first time that the cells and organs of a living animal could be rejuvenated
[5].
For the study, the
researchers used a specially engineered progeric
mouse designed to age more rapidly than normal as well as an engineered
normally aging mouse strain. Both types of mice were engineered to express the
Yamanaka factors when they came into contact with the antibiotic doxycycline,
which was given to them via their drinking water.
They allowed the
Yamanaka factors to be transiently expressed by including doxycycline in the
water for two days then removed it so that the OSKM genes were silenced again.
The mice then had a five-day rest period before another two days of exposure to
doxycycline; this cycle was repeated for the duration of the study.
Partial cellular
reprogramming
After just six weeks
of this treatment, which steadily reprogrammed the cells of the mice, the
researchers noticed improvements in their appearance, including reduced
age-related spinal curvature. Some of the mice from both experiment and control
groups were also euthanized at this point so that their skin, kidneys,
stomachs, and spleens could be examined. The control mice showed a range of
age-related changes compared to the treated mice, which had a number of aging
signs halted or even reversed, including some epigenetic alterations.
The treated mice also
experienced a 50% increase in their mean survival time in comparison to
untreated progeric control mice. It should be noted
that not all aging signs were affected by partial cellular reprogramming, and
if treatment was halted, the aging signs returned.
Perhaps most importantly,
while the partial cellular reprogramming conducted in this periodic manner
reset some epigenetic aging signs, it did not reset cell differentiation, which
would cause the cell to revert to an embryonic state and forget what kind of
cell it previously was; as you can imagine, this would be a bad thing in a
living animal.
Finally, not only did
the transient expression of Yamanaka factors at least partially rejuvenate
cells and organs in progeric mice, but it also
appeared to improve tissue regeneration in the engineered 12-month-old normally
aging mouse group. The researchers observed that the partial reprogramming
improved these mice’s ability to regenerate tissue in the pancreas, resulting
in an increased proliferation of beta cells; additionally, there was an
increase of satellite cells in skeletal muscle. Both of these types of cells
typically decline during aging.
Yamanaka factors used
to improve cognitive function in old mice
In October 2020,
another study took us a step close to partial cellular reprogramming reaching
the clinic when researchers showed that partial cellular reprogramming improves
memory in old mice. As the previous studies have shown, partial cellular
reprogramming is a balancing act between epigenetically rejuvenating cells and
resetting their aging clocks, without completely resetting their cell identity
so they forget what kind of cell they are [6].
Previous studies have
also shown us that this balancing act is possible and that by exposing cells
just long enough to the reprogramming factors, rejuvenation of the cell is
possible without erasing its cellular identity.
As in the previous
study we talked about, mice in this study had their cells engineered to react
to doxycycline, a common antibiotic used in veterinary practice, in order to
express the OSKM reprogramming factors. The researchers found that giving the
mice just enough exposure improved their cognitive function without an increase
in mortality during a four-month period.
Another step forward
for partial cellular reprogramming
In late 2020,
researchers, including Dr. David Sinclair, published a study that showed that
they had managed to restore lost vision to old mice, and mice with damaged
retinal nerves, using partial cellular reprogramming [7].
To reduce cancer risk
they opted to try partial cellular reprogramming minus one of the Yamanaka
Factors. One of the study authors, Dr. Yuancheng Lu,
was looking for a safer way to rejuvenate aged cells, as there were some
concerns that using c-Myc could cause cancer under
certain circumstances. So in the end they opted to use just Oct4, Sox2, and
Klf4 (OSK).
The good news was
that even OSK was able to rejuvenate the damaged eye nerves in mice and restore
vision. It also worked to improve age-related vision impairment in treated mice
and in mice that experienced increased eye pressure, an emulation of glaucoma.
Study co-author, Dr.
David Sinclair, said in an article in Nature, “We set out with a question: if
epigenetic changes are a driver of ageing, can you reset the epigenome?”, or,
in other words, “Can you reverse the clock?”. The answer to that appears to be
a resounding yes!
efining the partial cellular
reprogramming method
In January 2021
researchers showed that partial reprogramming rejuvenates human cells by 30
years, making old worn out cells function like the cells of a person around 25
years old. The researchers of this study used an approach that exposed cells to
enough reprogramming factors to push them beyond the limit at which they were
considered somatic rather than stem cells – but only just beyond [8].
The fibroblasts that
were reprogrammed in this way retained enough of their epigenetic cellular
memories to return to being fibroblasts once again. Exposing these cells to the
OSKM factors was performed with a doxycycline-activated lentiviral package as
previous animal studies had also done.
Perhaps most
interesting, according to Horvath’s 2013 multi-tissue clock, sample cells that
were just under 60 years old became epigenetically equivalent to cells that
were approximately 25 years old after 13 days of partial cellular
reprogramming, and the Horvath 2018 skin and blood clock showed that cells that
were approximately 40 years old were also epigenetically returned to those of a
25-year-old. It seems that the cells revert an epigenetic age of 25 or so
suggesting this is a peak of cellular prime or the optimal functional age for
cells.
The future potential and
challenges ahead for partial cellular reprogramming
By far, the biggest
hurdle to translating partial cellular reprogramming to people is the need to
find a way to activate the Yamanaka factors in our cells without needing to
engineer our bodies to react to a drug such as doxycycline. Doing this may
require us to develop drugs capable of activating OSKM, editing every cell in
our body to respond to a particular compound like doxycycline, which would be
extremely challenging though plausible.
Another possibility
is editing the germline so that our children are born with such a modification
to respond to a chosen compound, an idea that is currently an ethical nightmare
to even consider, not to mention the technical challenges of doing so
successfully. Whatever the solution is, it needs to be practical.
The other major
hurdle is to find a method suitable for the long term that does not require
constant upkeep, lest the aging signs return rapidly, as they did in mice when
treatment was interrupted. While there is some reason to believe that these
signs would not return as rapidly in people given the differences between mouse
and human metabolisms and our superior repair systems, it would likely return
in due course. So, finding a cost-effective way to keep the cyclic treatment
going is paramount; this could potentially be achieved using drugs or transient
gene therapy.
Conclusion
Assuming that these
barriers can be overcome, and the rapid advances in biotechnology offer a
reason to think that they will, then partial cellular reprogramming could
feasibly hold a great deal of potential for preventing or even curing the
diseases of aging.
One might envision an
early, first-pass use of this approach in a preventative way: older people at
risk of age-related diseases could be given partial reprogramming in order to
halt or at the least significantly slow down this aspect of aging and thus
reduce their risk of developing age-related diseases.
More refined stages
may see it being used in a more focused manner to repair a certain organ or
tissue damaged by injury or disease. In another, more advanced, scenario, the
gradual whole-body rejuvenation of older people might be attempted in order to
totally prevent age-related diseases and keep them healthy, active and able to
continue enjoying life.
Companies such as
Google Calico are also currently investigating alternative ways to achieve
partial cellular reprogramming without using Yamanaka factors. This is another
direction of research that may prove more practical and safer than using
Yamanaka factors.
The rapid progress of
medical technology could potentially mean that such partial cellular
reprogramming therapies may become available in the not too distant future. We
certainly hope so.
Health benefits of Irisin:
1. Balances Blood
Sugar And Fights Diabetes
Irisin improves blood
sugar regulation. It increases glucose tolerance and reduces
insulin resistance.
Irisin signals via
AMP-activated kinase (AMPK) pathway to mediate glucose uptake and
fatty acid oxidation.
It also lowers hemoglobin A1c.
Irisin may also play
an important role in the regulation of maternal–fetal glucose
homeostasis. Low
levels of irisin is associated with impaired carbohydrate metabolism
in infants.
In animal models with
Type 1 Diabetes, irisin helped repair cells.
2. Improves Weight
Loss
Irisin improves
weight loss by inducing PGC1a.
PGC1a is induced in
muscle by exercise and stimulates many of the best known
beneficial effects of
exercise in muscle: mitochondrial biogenesis, angiogenesis and
fiber-type switching.
PGC1a induces FNDC5.
FNDC5 is the precursor of irisin.
FNDC5 promotes the
conversion of white fat to brown fat (thermogenesis via PPARa).
FNDC5 influneces UCP1, which also contributes to the browning of
white fat.
Brown fat has more
mitochondria than white fat, so it is able to burn faster and give
you more energy.
Irisin can also
decrease food intake.
When rats were
injected with irisin into the hypotalamus, they ate
less.
3. Supports The
Skeletal System
In mice, irisin
released from skeletal muscle during exercise acts directly on bone
by increasing
cortical bone mineral density, bone perimeter and polar moment of
inertia.
It may promote bone
formation so that bones can better adapt to the increased load
during persistent
exercise.
It can do it without
browning response of adipose tissue when given at a lower dose.
It may help with osteoperosis.
It also provides
resistance to muscular dystrophy and denervation-linked muscular
atrophy.
Irisin has also been
shown to be positively correlated with bone mineral density in
adolescent women.
4. Is Anti-Aging
Irisin legnthens telomeres. Telomere shortening is a genetic
marker of aging.
Irisin also decreases
with age. Increasing irisin may therefore decrease aging.
5. Has Anti-Cancer
Effects
Irisin expression may
help hepatic cancer. It has also shown to protect normal cells
and create apoptosis
(cell death by 22-fold) in cancer cells.
Irisin levels are
lower in hepatic and breast cancers, suggesting a possible
protective role.
6. Protects The
Heart, Brain and Vascular System
A mouse study showed
that irisin might have a preventive role in atherosclerosis.
Administration of
irisin protected against endothelial injury and ameliorated
atherosclerosis by
inhibition of oxidative stress.
Also, irisin
decreased the plaque area and the infiltrating macrophages and T
lymphocytes in the
plaques, and down-regulated the mRNA expression of inflammatory
cytokines in the
aortas.
Higher irisin levels
may contribute lower total cholesterol in both men and women.
It also decreases the
oxidative stress from LDL cholesterol.
In rats with
hypertension, irisin was able to lower blood pressure by increasing
nitric oxide (via
AMPK-Akt-eNOS- NO Pathway).
HDAC4 overexpression
can induce cell death, increase lactate leakage, and
mitochondrial
dysfunction. Irisin is able to significantly attenuate all of these
effects and help with
reoxygenation, making it beneficial for stroke, heart attack,
and other hypoxic
events.
Thus, irisin may be
the reason why we don't suffocate in anaerobic exercise.
7. Is An
Anti-Inflammatory And Anti-Oxidant
Irisin can attenuate
inflammation of macrophages (shifting them towards a M2 state).
It can also reduce levels
of IL-6, TNF-alpha, MIP-1a, and MIP-1ß.
Irisin can prevent
oxidative stress in the liver (through the inhibition of protein
arginine
methyltransferase-3).
Since irisin works on
UCP1, it can decrease reactive oxygen species (ROS).
8. Is An Anti-Depressant
In an animal study,
irisin was able to ameliorate depressive-like behaviors by
regulating energy
metabolism.
9. Increases Brain
Function And Motivation
Irisin increases
cognitive function.
In animals, FNDC5
inhibition reduces neurogenesis, while overexpression stimulates
neural
differentiation.
It can also increase
brain derived neurotrophic factor (BDNF). By working on BDNF,
irisin may also work
on the dopaminergic system, enhancing the motivation/reward
system.
Irisin also works on
GABA and the GABAergic system.
Dysfunction of the
GABAergic system may contribute to cognitive impairment in humans.
Specifically,
individuals with Alzheimer’s Disease have decreased cerebral GABA in
the brain and CSF50.
Furthermore, GABA levels in human CSF decrease with aging,
which has been
associated with cognitive impairment.
The expression of
irisin in the GABAergic brain cells might, to some extent, explain
its effects on the
central nervous system-mediated functions.
Irisin upregulates
PGC-1a. PGC1a deficient mice show a significant brain deficiency.
PGC-1a is usually
under-expressed in Parkinson’s Disease and Lewy body disease patient
PGC-1a by dietary
treatment might benefit cognitive function and synaptic plasticity
in Alzheimer’s
disease by preventing Aß production in the brain.
https://mybiohack.com/blog/irisin-fndc5-ppar-alpha-ucp1
Earth's Atmospheric Oxygen Levels Continue Long Slide
https://www.livescience.com/56219-earth-atmospheric-oxygen-levels-declining.html
Hyperbaric
oxygen therapy increases telomere length and decreases immunosenescence
in isolated blood cells : a prospective trial Israeli scientists say they have
managed to successfully reverse the biological aging process – using only
oxygen.
https://paperchase-aging.s3-us-west-1.amazonaws.com/pdf/5fa17ba097f8730007f0c2c5.pdf
https://www.aging-us.com/article/202188/text
Israeli scientists claim to reverse aging process
“We are going
backwards in time,” Prof. Shai Efrati said.
NOVEMBER 21, 2020 19:55
Hyperbaric oxygen therapy chamber at Aviv Clinic in Florida
(photo credit: AVIV CLINIC)
Israeli scientists say they have managed to successfully reverse
the biological aging process
– using only oxygen.
Recent research led
by Tel Aviv University’s Prof. Shai Efrati, together with a team from Shamir
Medical Center, found that when healthy adults
over the age of 64 were placed in a pressurized chamber and given pure oxygen
for 90 minutes a day, five days a week for three months, not only was the aging
process delayed - it was actually reversed.
Israeli scientists say they have managed to successfully reverse
the biological aging process
– using only oxygen.
Recent research led
by Tel Aviv University’s Prof. Shai Efrati, together with a team from Shamir
Medical Center, found that when healthy adults
over the age of 64 were placed in a pressurized chamber and given pure oxygen
for 90 minutes a day, five days a week for three months, not only was the aging
process delayed - it was actually reversed.
Israeli scientists say they have managed to successfully reverse
the biological aging process
– using only oxygen.
Recent research led
by Tel Aviv University’s Prof. Shai Efrati, together with a team from Shamir
Medical Center, found that when healthy adults
over the age of 64 were placed in a pressurized chamber and given pure oxygen
for 90 minutes a day, five days a week for three months, not only was the aging
process delayed - it was actually reversed.
Specifically, the study, which is published in the peer-reviewed
journal Aging,
focused on whether the process could reverse two key indicators of biological
aging: the shortening of DNA telomeres and the accumulation of resultant
senescent cells.
A telomere is the end of a chromosome. Telomeres are made of
repetitive sequences of non-coding DNA that serve as bumpers to protect the
chromosome from damage during replication. Every time replication happens,
these bumpers take a hit, making them shorter and shorter. Once the telomere
reaches a certain length, the cell cannot replicate anymore, which leads to
senescent cells: aging, malfunctioning cells that ultimately lead to cognitive
or other age-related disabilities and even diseases, such as cancer.
Some 35 adults over the age of 64 were involved in the study and
were administered hyperbaric oxygen therapy (HBOT) utilizing 100% oxygen in an
environmental pressure higher than one absolute atmospheres to enhance the
amount of oxygen dissolved in the body's tissues.
Every 20 minutes, the participants were asked to remove their
masks for five minutes, bringing their oxygen back to normal levels. However,
during this period, researchers saw that fluctuations in the free oxygen
concentration were interpreted at the cellular level as a lack of oxygen –
rather than interpreting the absolute level of oxygen.
In other words, repeated intermittent hyperoxic
(increased oxygen level) exposures induced many of the mediators and cellular
mechanisms that are usually induced during hypoxia (decreased oxygen levels) –
something Efrati explained is called the hyperoxic-hypoxic
paradox.
“The oxygen fluctuation we generated is what is important,” he
told The
Jerusalem Post. “During this process, a state of oxygen shortage
resulted, which caused cell regeneration.”
The
inside of a hyperbaric oxygen therapy chamber at Aviv Clinic in Florida
(Credit: Aviv Clinic)
The practical ramifications include improvements in attention,
information processing speed and executive functions, which normally decline
with aging and about which more than 50% of people over the age of 60 express
concern. According to the study, the changes were equivalent to how the
participants’ bodies were at the cellular level 25 years earlier.
“We are not [just] slowing the decline - we are going backwards
in time,” Efrati said.
Efrati has been studying the aging process for a decade and runs
the Aviv Clinics in Florida. This study, he said, is proof that the cellular
basis for the aging process can be reversed, adding that it “gives hope and
opens the door for a lot of young scientists to target aging as a reversible
disease.” It could also enable doctors and scientists to find a way to monitor
telomere length and develop medications that could help them grow back when
needed.
Will it make people live longer?
The effect’s duration is yet to be determined in the long-term,
Efrati said. But “probably yes. We know that people with shorter telomeres die
earlier, so it makes sense.”
One disadvantage of the study was its limited sample size.
Efrati added the experiment was conducted using a scientific,
monitored HBOT chamber and people should not try this at home. He said, “There
is a lot of junk out there” claiming sacs inflated with air are hyperbaric
treatments. “This is not what is being used in the studies, it is not effective
– and moreover, it could be dangerous.”
d
|
Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective
trial
, ,,, ,,,
- 1 Research and Development Unit, Shamir Medical Center, Zerifin, Israel
- 2 The Sagol Center
for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical
Center, Zerifin, Israel
- 3 Sackler School of Medicine, Tel-Aviv
University, Tel-Aviv, Israel
- 4 Bar Ilan
University, Ramat-Gan, Israel
- 5 Sagol School of
Neuroscience, Tel-Aviv University, Tel-Aviv, Israel
* Equal
contribution
Received: September
3, 2020 Accepted: October
22, 2020 Published: November
18, 2020
https://doi.org/10.18632/aging.202188
Abstract
Introduction: Aging is characterized by the progressive
loss of physiological capacity. At the cellular level, two key hallmarks of the
aging process include telomere length (TL) shortening and cellular senescence.
Repeated intermittent hyperoxic exposures, using
certain hyperbaric oxygen therapy (HBOT) protocols, can induce regenerative
effects which normally occur during hypoxia. The aim of the current study was
to evaluate whether HBOT affects TL and senescent cell concentrations in a
normal, non-pathological, aging adult population.
Methods: Thirty-five healthy independently
living adults, aged 64 and older, were enrolled to receive 60 daily HBOT
exposures. Whole blood samples were collected at baseline, at the 30th and
60th session, and 1-2 weeks following the last HBOT session. Peripheral
blood mononuclear cells (PBMCs) telomeres length and senescence were assessed.
Results: Telomeres length of T helper, T
cytotoxic, natural killer and B cells increased significantly by over 20%
following HBOT. The most significant change was noticed in B cells which
increased at the 30th session, 60th session and post HBOT by
25.68%±40.42 (p=0.007), 29.39%±23.39 (p=0.0001) and 37.63%±52.73 (p=0.007),
respectively.
There was a significant decrease in the
number of senescent T helpers by -37.30%±33.04 post-HBOT (P<0.0001).
T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59
(p=0.0004) post-HBOT.
In conclusion, the study indicates that HBOT
may induce significant senolytic effects including
significantly increasing telomere length and clearance of senescent cells in
the aging populations.
http://inventorspot.com/articles/go-abudhabi-get-younger-human-regenerator
REGENERATION ; bullet shaped cocoon pivots 90 degrees so your body
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http://rexresearch.com/quantregen/quantregen.htm
LONGEVITY LINK :
http://rexresearch.com/1index.htm#longevity
Longevity / Rejuvenation --- Astragalus &
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BRUSHKOV: Bacillus cereus sp. F Longevity ** COTSARELIS: Hair Regrowth **
CROCK: Aura Therapy ** Cymatherapy ** DAVIS / RAWLS:
Biomagnetism ** DePINHO: Age Reversal ** DOTTO:
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/ AmeriScience: AS10 Rejuvenation ** KASAREV: Scenar ** KHAVINSON: Epitalin **
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Extension ** NAKANISHI: Cabenegrin Resurrection **
PETYAEV: Anti-Aging Chocolate ** QUINTON: Ocean Plasma ** ROBERTSON: Revital ** SHARPE: Tooth Regrowth ** SHCHEPINOV: Deuterated
Nutrients ** SHEALY: DNA Telomere Rejuvenation ** SINCLAIR: Nicotinamide vs
Ageing ** SKULACHEV: SkQ ** TAIMURAZOVICH: Quantum
Regeneration ** Super-Light Water ** Urine Therapy ** ZUROVCIK: Wound-Healing
Device *
» LORIN, Christian: Monopolar Electromagnet ~ 9
Patents.
» LU, Yi.: DNA-Au Nanocrystals ~ Au crystalizes on
DNA in geometric forms: star, hexagon, circle, &c. Plus: the related theory
by Rafiki... inspiring possibilities...
» LUCAS, Tim: Macrosonic
Resonant Synthesis ~ Standing wave resonator increases acoustic power 1600x;
articles & patents ( got infrasound ? ).
https://ediovision.blogspot.com/2018/09/rex-research.html
Electric Fields Kill Tumors - A promising device
uses electric fields to destroy cancer cells in the brain.
http://rexresearch.com/palti/palti.htm
"direct transfer of the information from one
biological object to another by radio waves "
http://rexresearch.com/kanchzhen/kanchzhen.htm
Sound / Ultrasound: A4 = 432 Hz ** BILLINGTON:
Sonic Agriculture ** BOSCH: Acoustic Washing Machine ** CHEN: Ultrasonic Tooth
Regeneration ** COTTELL: Ultrasonic Fuel-Water Burner ** DARAIO: Sonic Bullets
** DAVEY: Sonic Resonance Boiler ** FLANAGAN: Neurophone
** FRIDMAN: Shock-Wave Generator ** GRIGGS: Hydrosonic
Pump ** GRITSKEVITCH: Hydro-Magnetic Generator ** HELMHOLTZ: Resonator **
JENNY: Cymatics ** KEELY: Motor ** KEELY: Aetheric Generator ** KEELY: Atomic
& Molecular Triplets ** KENT: SASER ** LEIGHTON / BIRKIN: Ultrasonic Nozzle
** LEINENGA / GÖTZ: Ultrasound vs Alzheimer's Disease ** LUCAS: Macrosonic Resonant Synthesis ** McCLAIN
/ WOOTAN: Magnetic Resonance Amplifier (MRA) (#1) ** McGUIRE:
Acoustic Insect Repellant ** MOMEN: Ultrasonic Dryer ** NORRIS: Parametric Hypersound ** EM Treatments of Coal **
http://rexresearch.com/1index.htm#sound
Herbs: Apoptosis of Cancer by Natural Substances
** Astragalus & Longevity ** Birth Control ** Bloodroot vs Cancer **
CAMPBELL-TOFTE: Rauvolfia Vomitoria vs Diabetes **
Catnip ** Curcumin ** DANG: Papaya vs Cancer ** Frankincense vs Cancer **
GORDON: Blushwood vs Cancer ** Herbs vs Halitosis **
Herbs vs AIDS ** Herbs vs Arthritis ** Herbs vs Diabetes ** Herbs vs Hepatitis
** HUN: Kumdang-2 ** MICHELOW: Griffithsin vs Ebola
Virus ** Milkwood vs Cancer ** Moringa ** NAKANISHI: Cabenegrin
Resurrection ** Olive Leaf ** PANDEY: Dandelion vs Cancer ** Pine Pollen **
POSNER: Artemisinin Malaria Cure ** Purple Nutsedge vs Tooth Decay ** QUAVE:
Botanicals vs MRSA ** SHUKLA: Fenugreek Food Preservation ** Sutherlandia vs Cancer ** Thunder God Vine vs Cancer **
Turmeric / Curcumin ** Turmerone ** Cannabis & Health (2004-05) * Hemp
& Health **
http://rexresearch.com/1index.htm#herbs
Electrotherapy:** AKIMOV: Torsion Field Generators
** BAUGH: Rejuvenation ** BOEHM: DNA Resonant Frequencies ** CROCK: Aura
Therapy ** DAVALOS / RUBISKY: Irreversible Electro-Poration
vs Cancer ** DAVIS / RAWLS: Biomagnetism ** DOTTO: Diamagnetic Ring ** DOUGAL:
Infrared Therapy ** EEMAN: Co-Operative Healing ** EGELY: Bio-Energetic Devices
** EGELY / VESELY: Bio-Induced Magnetic Anomalies ** Electrostatic Therapy
Patents ** GIANSANTI Copper Mask ** GOLBERG: PEMF Preservation of Milk **
JOHNSON ( J. ): Dipole Resonance Mutation ** KAALI / SCHWOLSKY: Blood
Electrification vs AIDS ** KALININ: Munich Jar ** KAN'CHZHEN: Microwave Transfer
BioInfo ** KASAREV: Scenar
** LAKHOVSKY: MWO ** NORDENSTROM: Electricity vs Cancer ** PALTI: Electric
Fields & Frequencies vs Cancer ** PASCHE: EMF Cancer Therapy ** SCHOENBACH:
Nanosecond Pulsed Electric Fields ** Quantum Regeneration ** SMIRNOV: EM Shield
** Torsion Field GeneratorsTorsion Field ( I ) **
TROFIMOV: Hypo-Magnetic Chamber **
http://rexresearch.com/1index.htm#electrotherapy
Rex Research was established in 1982 by Robert A.
Nelson to archive and distribute " InFolios
" -- Information Folios -- of collected Articles about suppressed,
dormant, or emerging Sciences, Technologies, Inventions, Theories, Therapies,
& other Alternatives that offer real Hope & Choices to help Liberate
Humanity from its Stupidity and the evile Pornocracy
of Psychopaths .
Freedom (TM), Truth (TM), Love (TM) & Earth
(TM) are gravely wounded, & Time (TM) is accelerating / compressing --
running out, along with the Oxygen (TM) & Oil (TM) & Money (TM) &
Luck (TM) & Stuff (TM) -- in these Latter Days of this era of
"Civilization" as we knew it...
https://ediovision.blogspot.com/2018/09/rex-research.html
Cancer: ANTELMAN: TetraSilver
TetraOxide ** ANTELMAN: TetraCopper
Tetroxide ** Maple Syrup / Baking Soda vs Cancer ** BECKER: Silver
Iontophoresis ** BECKER: Anti-Aging Machine * Bloodroot vs Skin Cancer **
BURZYNSKI: Antineoplaston Therapy ** Cesium Chloride
vs Cancer ** Cockroach Medicine ** DANG: Papaya vs Cancer ** DARAIO: Sonic
Bullets ** DAVALOS / RUBISKY: Irreversible Electro-Poration
vs Cancer ** DCA vs Cancer ** DMSO Therapy ** DOTTO: Diamagnetic Ring ** DUFES:
Bioactive Polymers vs. Cancer ** Frankincense vs Cancer ** Geranium vs HIV/AIDS
** Ginger vs Cancer **GOLD: Hydrazine Sulfate vs Cancer ** GORDON: Blushwood vs Cancer ** GWYNN: Chlorozone
vs Cancer ** HALSTEAD: Cancer Therapy ** HOLT: Cancer Therapy ** KAALI /
SCHWOLSKY: Blood Electrification vs AIDS ** KASHFI: NOSH-Aspirin vs Cancer **
KOCH: Glyoxylide Therapy ** LITTRUP: Cryotherapy vs
Cancer ** LIVINGSTON: Cancer Therapy ** Mebendazole vs Cancer ** Milkwood vs
Cancer ** NAESSENS: Somatoscope / 714X **
NORDENSTROM: Electricity vs Cancer ** Ozone Therapy ** PALTI: Electric Fields
& Frequencies vs Cancer ** PANDEY: Dandelion vs Cancer ** PASCHE: EMF
Cancer Thereapy ** Pine Pollen ** POPP: Mistletoe vs
Cancer ** PRIORE: ElectroTherapy ** QUINTON: Ocean
Plasma ** REVICI: Selenium vs Cancer ** RIFE: Beam Ray Machine ** SAVAGE:
CSA-25 vs AIDS** SCHOENBACH: Nanosecond Pulsed Electric Fields ** SIMONCINI:
Baking Soda vs Candida & Cancer ** SOLOMIDES: Physiatrons
vs Cancer ** Sutherlandia vs Cancer ** TetraSilver Tetroxide ( # 5 ) ** Thunder God Vine vs Cancer
** Turmeric / Curcumin ** Ozone Dentistry ** Hydrogen Peroxide Therapy **
WAINWRIGHT: Ozone therapy ** YE: Gold Nanotubes vs Cancer ** Urine Therapy *
https://ediovision.blogspot.com/2018/09/rex-research.html
Health: ADAMS: Cesium Eliminator ** AKIMOV:
Torsion Field Generators ** ANTELMAN: TetraSilver TetraOxide ** ANTELMAN: TetraCopper
Tetroxide ** Activated Water Patents ** ATP Extraction Patents ** BADYLAK:
Organ Regeneration ** BARE: Frequency Therapy ** BAUGH: Rejuvenation ** Baking
Soda vs Cancer ( (II ) ** Baking Soda / Molasses vs Cancer ** BECHAMP: Microzymes ** BECKER: Silver Iontophoresis ** BECKER:
Anti-Aging Machine ** BECKETT: Mg-Carbonate Water ** BELFOR: Homeoblock ** BELOSEVIC: Ozone vs Prions ** BENEDICT:
Phototherapy ** BENENATI: Mummification ** BENNETT: Rejuvenation ** BENVENISTE:
Homeopathy & Digital Biology ** Bioenergetic Patents ( II ) ** Biophoton
Patents ** Biophoton Research Papers ** Birth Control ** BLAU: Rapid Telomere
Extension ** Bloodroot vs Skin Cancer ** BOEHME: DNA Resonance ** BOVIS:
Biometer ** BRUSHKOV: Bacillus cereus sp. F Longevity ** BURZYNSKI: Antineoplaston Therapy ** CAMPBELL-TOFTE: Rauvolfia Vomitoria vs Diabetes ** Carbamide Peroxide Teeth
Whitening ** CARSON: Emergency Childbirth ** Cesium Chloride vs Cancer **
CHAUSOVSKY: Technotronic Psychotechnology ** CHEN:
Ultrasonic Tooth Regeneration ** Cobalt Hexamine vs Ebola ** Cockroach Medicine
** Compost Toilets ** Copper Medicine ** COTSARELIS: Hair Regrowth ** CRILE: Radiogens ** Crocodylus Porosus Peptide ** CROCK: Aura Therapy ** Cymatherapy ** DANG: Papaya vs Cancer ** DARAIO: Sonic
Bullets ** DAVALOS / RUBISKY: Irreversible Electro-Poration
vs Cancer ** DAVIDOVITCH: Electro-Orthodontia ** DAVIS / RAWLS: Biomagnetism**
Dental Electrolysis ** DePINHO: Age Reversal **
Distilled Water & Health ** DCA vs Cancer ** DMSO Therapy ** DOTTO:
Diamagnetic Ring ** DOUGAL: Infrared Therapy ** DUFES: Bioactive Polymers vs.
Cancer ** Ebola Patents ** Ebola Therapies ** EEMAN: Co-Operative Healing **
EGELY: Bio-Energetic Devices ** EGELY / VESELY: Bio-Induced Magnetic Anomalies
** EISING: Radolatum ** Electrolyzed Water** Electro-OsteoGenesis ** Electrostatic Therapy Patents ** ENGEL:
Living Alcohol ** EnWave: Dehydration System ** Field
Manuals ** FLANAGAN: Neurophone ** Frankincense vs
Cancer ** FRODSHAM: Magnetic Sepsis Filter ** FUCHS: Beta-Catenin vs Alopecia
** GAJAREV / POPONIN: DNA Reprogramming ** GAJAREV: Wave Genetics ( II ) ** GcMAF ** Geopathic Zones ** Geranium vs HIV/AIDS **
GIANSANTI: Copper Mask ** GILBERT: DD107498 vs Malaria ** Ginger vs Cancer **
GOLD: Hydrazine Sulfate vs Cancer ** GOLOD: Pyramid Devices ** GORDON: Blushwood vs Cancer ** GUASCO: Theta Amplifier ** GUDKOV:
Flagellin vs Radiation ** GWYNN: Chlorozone vs Cancer
** HALSTEAD: Cancer Therapy ** HAMILTON: Chlorine Dioxide ** Herbs vs Halitosis
** Herbal Contraception ** HOLT: Cancer Therapy ** HONTSU: Tooth Patch ** Human
Growth Hormone Precursors ** HUMBLE: ClO2 vs Malaria ** HUN: Kumdang-2 **
IGHINA: Elios ** ISTRATE: Celulact H ** JOHNSON ( J.
): Dipole Resonance Mutation ** JIANG: Plasma Dental Probe **
JONES/AMERISCIENCE: AS10 Rejuvenation ** JUDD: Tooth Remineralization ** KAALI
/ SCHWOLSKY: Blood Electrification vs AIDS ** KALININ: Munich Jar ** KARIM: Biogeometry ** KAN'CHZHEN: Microwave Transfer BioInfo ** KASAREV: Scenar **
KASHFI: NOSH-Aspirin vs Cancer ** KEENER: Cold Plasma Food Preservation **
KENT: KISSCare ** KHAVINSON: Epitalin
** KIEFER: Vomit Beam ** KITT: Stabilized DeHydroAscorbic
Acid ** KOCH: Glyoxylide Therapy ** KOH:
Vibration-Accelerated Wound-Healing ** KORSCHELT: Etheric Radiations **
KRAVCHENKO: Biological Anomaly Detectors ** Lactucarium / Lettuce Opium **
LAKHOVSKY: MWO ** LANDOLINA: Veti-Gel Bandage ** Le
RIBAULT: Organo-Silicon Therapy ** LEINENGA / GÖTZ: Ultrasound vs Alzheimer's
Disease ** LIH: LifeVac Anti-Choke Device **
LIVINGSTON: Cancer Therapy ** LO / GANN: Cluster Water ** LYNGSTADAAS: Bone
Scaffold ** LITTLEFIELD: Resurrection Salt ** LITTRUP: Cryotherapy vs Cancer **
MACIEL: Tilapia Skin Burn Bandage ** MAO: Tooth Regeneration ** MARTA:
Polarized Light Therapy ** Mebendazole vs Cancer ** MERKL: Chondriana
& Life Crystals ** MIELKE: Prion Disinfectant ** Milkwood vs Cancer **
MOHINDRA: OraLift ** MONTAGNIER: DNA Teleportation **
MORFILL: Plasma Sterilization ** Moringa ** MOUSSAD: Lipofullerene
Life Extension ** NAESSENS: Somatoscope / 714X **
NAKANISHI: Cabenegrin Resurrection ** Nanobubble
Water ** NEISTER: Sterilray ** NELSON: Diabetes
Treatment ** NEMES: Microscope ** NEWNHAM: Borax vs Arthritis** NORDENSTROM:
Electricity vs Cancer ** ODON: Childbirth Device ** Olive Leaf ** OLNEY: UV
Blood Irradiation Therapy ** Orgone Patents ** Ozone Therapy ** PALTI: Electric
Fields & Frequencies vs Cancer ** PAN: Channelrhodopsin
vs Blindness ** PANDEY: Dandelion vs Cancer ** PASCHE: EMF Cancer Thereapy * PETERSEN.: No-Mesh Hernia Surgery * PETYAEV:
Anti-Aging Chocolate ** PFEIFFER: Sensitive Crystallization Processes **
PICCARDI: Chemical Basis of Medical Climatology ** Pine Pollen * PITTS: Dental
Iontophoresis ** Plant Milk ** POPP: Mistletoe vs Cancer ** POSNER: Malaria
Cure ** PRIORE: ElectroTherapy ** Purple Nutsedge vs
Tooth Decay ** Pyorrhea Patents ** Pyramid Patents ** Pyramid Energy Patents (
II ) ** QUAVE: Botanicals vs MRSA ** QUINTON: Ocean Plasma ** Radiesthesia
Patents ** REICH: Orgone ** REVICI: Selenium vs Cancer ** RICKARD: L-Arginine
vs Plaque ** RIFE: Beam Ray Machine ** ROBERTSON: Revital
** ROFFE: Harmonic Resonance ** ROWEN: Ozone vs Ebola** RUBTSOV: Puke Ray **
RUSS: Eye-Ray Device ** SARIKAYA: Tooth Remineralization ** SAVA: Prion
Disinfection ** SAVAGE: CSA-25 vs AIDS ** SCHIFFER / BUCK: Therapeutic Glasses
** SCHOENBACH: Nanosecond Pulsed Electric Fields ** SCHWARTZ: Spray-On Glass **
SEDYLMAR: Microwave Still ** SHARPE: Tooth Regrowth ** SHCHEPINOV: Deuterated
Nutrients ** SHEALY: DNA Telomere Rejuvenation ** SHIRONOSOV: Activated Microcluster Water ** SHUKLA: Fenugreek Food Preservation
** Silicic Acid & Health ** SIMONCINI: Baking Soda vs Candida & Cancer
** SKULACHEV: SkQ** Sleep ** SMIRNOV: EM Shield **
SOLOMIDES: Physiatrons vs Cancer ** SOUTER: Water
Purification ** STARK: Water Purification ** STERNHEIMER: DNA Music **
Sulforaphane vs Cancer ** Sulforaphane Patents ** Sutherlandia
vs Cancer ** TetraSilver Tetroxide ( # 5 ) ** Thunder
God Vine vs Cancer ** TOBINICK: Etanercept vs Strokes ** Tooth Remineralization
** Torsion Field ( I ) ** Torsion Field Generators ** TSEN: UV Inactivation of
Viruses ** Turmeric / Curcumin ** WILLARD: Catalyst-Activated Water ** Cannabis
& Health (2004-05) ** Ozone Therapy ** Ozone Dentistry ** Hydrogen Peroxide
Therapy ** Super-Light Water ** Urine Therapy ** UVAROV: Egyptian Healing Rods
** WAINWRIGHT: Ozone therapy ** WURZBURGER: MgOH vs
MRSA ** YE: Gold Nanotubes vs Cancer ** YU: Plasma Dental Brush ** ZACHARAKIS:
T-Cell Therapy ** ZENG: Electro-Chemo-Acceleration ** ZHANG: Lanosterol vs
Cataracts ** ZUROVCIK: Wound-Healing Device ** InFolios
( PDF format ): Aphrodisiacs ** Hair
https://ediovision.blogspot.com/2018/09/rex-research.html
HEALTH LINK ; http://rexresearch.com/1index.htm#health
HYPOMAGNETIC CHAMBER : shields off the external
magnetic fields and this allows the organism to recuperate. The chamber's
influence can be tested with a normal magnetometer. It is constructed based on
permalloy steel and the Hemholtz coils.
http://rexresearch.com/trofimov/trofimov.html
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CategoryLife Extension News
Tags:Epigenetic Alterations, Epigenetics, Forever Healthy
Foundation, OSKM, Partial Cellular Reprogramming, Reprogramming
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